For instance, the levels of fatty acids with omega-3 unsaturation have been suggested to be important for health Riediger et al. Until now, no lipidomic studies have been performed analyzing the full diversity of lipidomes with respect to the influence of fatty acid content of the diet. Obviously, the diet can in the long run lead to imbalances and modulate the fine-tuning of lipid levels such that disease is caused, for instance myocardial infection through atherosclerosis Puska Here is an interesting new area of research that will profit from the enormous advances in lipid analyses by mass spectrometry Schwudke et al.
Inbuilt into the functions of the compositional diversity of all membranes, there must also be feedback mechanisms introducing robustness so that the structure and function of cellular membranes is maintained despite varying lipid intake.
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These are areas of research that can now be explored by multidisciplinary approaches. What is emerging from recent cell membrane research is a fascinating two-dimensional liquid equipped with remarkable properties. Most intriguing is the concept of collectives of lipids and proteins that work together to make cell membranes such incredible matrices for supporting and facilitating cellular function.
We thank Hermann-Josef Kaiser and Ilya Levental for reading the paper and the Simons lab for continuous critical input.
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Formation of Cell Membrane Component Domains in Artificial Lipid Bilayer
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