PDF An Introduction to Biological Membranes: From Bilayers to Rafts

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For instance, the levels of fatty acids with omega-3 unsaturation have been suggested to be important for health Riediger et al. Until now, no lipidomic studies have been performed analyzing the full diversity of lipidomes with respect to the influence of fatty acid content of the diet. Obviously, the diet can in the long run lead to imbalances and modulate the fine-tuning of lipid levels such that disease is caused, for instance myocardial infection through atherosclerosis Puska Here is an interesting new area of research that will profit from the enormous advances in lipid analyses by mass spectrometry Schwudke et al.

Inbuilt into the functions of the compositional diversity of all membranes, there must also be feedback mechanisms introducing robustness so that the structure and function of cellular membranes is maintained despite varying lipid intake.

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These are areas of research that can now be explored by multidisciplinary approaches. What is emerging from recent cell membrane research is a fascinating two-dimensional liquid equipped with remarkable properties. Most intriguing is the concept of collectives of lipids and proteins that work together to make cell membranes such incredible matrices for supporting and facilitating cellular function.

We thank Hermann-Josef Kaiser and Ilya Levental for reading the paper and the Simons lab for continuous critical input.

ISBN 13: 9780444521538

We also thank Doris Meder, especially for drawing Figure 3. Additional Perspectives on The Biology of Lipids available at www. Previous Section Next Section. Figure 1. View this table: In this window In a new window. Figure 2. Figure 3. Figure 4. Previous Section. Nat Cell Biol 10 : — Raft composition at physiological temperature and pH in the absence of detergents. Biophys J 94 : — CrossRef Medline Google Scholar. Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast.

Mol Biol Cell 12 : — Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc Natl Acad Sci 97 : — Analysis of the transmembrane domain of influenza virus neuraminidase, a type II transmembrane glycoprotein, for apical sorting and raft association. J Virol 74 : — Proc Natl Acad Sci : — Imaging of mobile long-lived nanoplatforms in the live cell plasma membrane.

Formation of Cell Membrane Component Domains in Artificial Lipid Bilayer

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Stillwell, An Introduction to Biological Membranes: From Bilayers to Rafts, 1e

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Cell Membrane Fluidity - Role of cholesterol

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Yeast lipids can phase-separate into micrometer-scale membrane domains. Traffic 4 : — Molecular dynamics and interactions for creation of stimulation-induced stabilized rafts from small unstable steady-state rafts. Traffic 5 : — Greasing their way: Lipid modifications determine protein association with membrane rafts. Biochemistry 49 : — Cholesterol-dependent phase separation in cell-derived giant plasma-membrane vesicles. Palmitoylation regulates raft affinity for the majority of integral raft proteins.

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