For instance, the levels of fatty acids with omega-3 unsaturation have been suggested to be important for health Riediger et al. Until now, no lipidomic studies have been performed analyzing the full diversity of lipidomes with respect to the influence of fatty acid content of the diet. Obviously, the diet can in the long run lead to imbalances and modulate the fine-tuning of lipid levels such that disease is caused, for instance myocardial infection through atherosclerosis Puska Here is an interesting new area of research that will profit from the enormous advances in lipid analyses by mass spectrometry Schwudke et al.
Inbuilt into the functions of the compositional diversity of all membranes, there must also be feedback mechanisms introducing robustness so that the structure and function of cellular membranes is maintained despite varying lipid intake.
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These are areas of research that can now be explored by multidisciplinary approaches. What is emerging from recent cell membrane research is a fascinating two-dimensional liquid equipped with remarkable properties. Most intriguing is the concept of collectives of lipids and proteins that work together to make cell membranes such incredible matrices for supporting and facilitating cellular function.
We thank Hermann-Josef Kaiser and Ilya Levental for reading the paper and the Simons lab for continuous critical input.
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We also thank Doris Meder, especially for drawing Figure 3. Additional Perspectives on The Biology of Lipids available at www. Previous Section Next Section. Figure 1. View this table: In this window In a new window. Figure 2. Figure 3. Figure 4. Previous Section. Nat Cell Biol 10 : — Raft composition at physiological temperature and pH in the absence of detergents. Biophys J 94 : — CrossRef Medline Google Scholar. Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast.
Mol Biol Cell 12 : — Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc Natl Acad Sci 97 : — Analysis of the transmembrane domain of influenza virus neuraminidase, a type II transmembrane glycoprotein, for apical sorting and raft association. J Virol 74 : — Proc Natl Acad Sci : — Imaging of mobile long-lived nanoplatforms in the live cell plasma membrane.
Formation of Cell Membrane Component Domains in Artificial Lipid Bilayer
J Biol Chem : — Membranes in balance: Mechanisms of sphingolipid homeostasis. Mol Cell 40 : — Cholesterol and the Golgi apparatus. Science : — Line active hybrid lipids determine domain size in phase separation of saturated and unsaturated lipids. Biophys J 98 : L21 — L Hybrid lipids as a biological surface-active component. Biophys J 97 : — Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68 : — J Lipid Res 50 : S15 — S Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles.
Stillwell, An Introduction to Biological Membranes: From Bilayers to Rafts, 1e
J Cell Biol : — Cytoskeleton—membrane interactions in membrane raft structure. Cell Mol Life Sci 66 : — Tuning lipid mixtures to induce or suppress domain formation across leaflets of unsupported asymmetric bilayers. Specificity of intramembrane protein—lipid interactions. Cold Spring Harb Perspect Biol 3 : a Membrane rafting: From apical sorting to phase segregation.
FEBS Lett : — Allosteric regulation of human EGF receptor by lipids. Proc Natl Acad Sci in press. Google Scholar. Membrane thickness cue for cold sensing in a bacterium. Curr Biol 20 : — Lipid raft organization and function in the small intestinal brush border. J Physiol Biochem 64 : — Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells.
Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers. Proc Natl Acad Sci 98 : — Biochem J : — Membranes are more mosaic than fluid.
Nature : — Glycosylphosphatidylinositol anchors. In Essentials of glycobiology , 2nd ed. Varki A , et al. Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells. Biochemistry 32 : — Contributions of Galectin-3 and -9 to epithelial cell adhesion analyzed by single cell force spectroscopy. Lipid polymorphisms and membrane shape. Cold Spring Harb Perspect Biol doi: Phospholipids undergo hop diffusion in compartmentalized cell membrane. The complex life of simple sphingolipids. EMBO 5 : — CrossRef Google Scholar. On bimolecular layers of lipoids on the chromocytes of the blood.
J Exp Med 41 : — Nanoclusters of GPI-anchored proteins are formed by cortical actin-driven activity. Cell : — The inner side of T cell lipid rafts. Immunol Lett 94 : — Dynamin and clathrin are required for the biogenesis of a distinct class of secretory vesicles in yeast. EMBO J 21 : — Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes.
Lipid rafts: Contentious only from simplistic standpoints. Nat Rev Mol Cell Biol 7 : — Distribution and functions of sterols and sphingolipids.
Lipid domain structure of the plasma membrane revealed by patching of membrane components. Parallel secretory pathways to the cell surface in yeast. Phase separation in lipid membranes. An introduction to critical points for biophysicists; observations of compositional heterogeneity in lipid membranes. Biochim Biophys Acta : 53 — Lipid rafts: At a crossroad between cell biology and physics. Nat Cell Biol 9 : 7 — Lipid components of two different regions of an intestinal epithelial cell membrane of mouse.
Biochim Biophys Acta : — Cholesterol is required for surface transport of influenza virus hemagglutinin. Transbilayer effects of raft-like lipid domains in asymmetric planar bilayers measured by single molecule tracking. Biophys J 91 : — Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans -Golgi network.
Yeast lipids can phase-separate into micrometer-scale membrane domains. Traffic 4 : — Molecular dynamics and interactions for creation of stimulation-induced stabilized rafts from small unstable steady-state rafts. Traffic 5 : — Greasing their way: Lipid modifications determine protein association with membrane rafts. Biochemistry 49 : — Cholesterol-dependent phase separation in cell-derived giant plasma-membrane vesicles. Palmitoylation regulates raft affinity for the majority of integral raft proteins.
Lipid rafts as a membrane-organizing principle. Science : 46 — Plasma membranes are poised for activation of raft phase coalescence at physiological temperature. Cholesterol-induced protein sorting: An analysis of energetic feasibility. Biophys J 84 : — Medline Web of Science Google Scholar. Phase coexistence and connectivity in the apical membrane of polarized epithelial cells.
Galectin-9 trafficking regulates apical-basal polarity in Madin—Darby canine kidney epithelial cells. Three-dimensional reconstruction of the membrane skeleton at the plasma membrane interface by electron tomography. Life—As a matter of fat. The emerging science of lipidomics , pp. Springer-Verlag , Heidelberg.
Lipids 39 : — Model answers to lipid membrane questions. Ultrafine membrane compartments for molecular diffusion as revealed by single molecule techniques. Biophys J 86 : — Coordination of lipid metabolism in membrane biogenesis. Annu Rev Cell Dev Biol 25 : — A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast.
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